PD-L2 蛋白, Cynomolgus (HEK293, Fc)

PDCD1LG2 is an immune checkpoint receptor ligand that binds to PD-1 to activate pathways that inhibit TCR/ BCR-mediated immune cell activation. PDCD1LG2 can inhibit T-cell proliferation and inflammatory cytokine production. The expression of PDCD1LG2 on mouse tumor cells inhibits cytotoxic T-cell-mediated immune responses and can be used as a biomarker or prognostic indicator. PD-L2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived PD-L2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-L2 Protein, Cynomolgus (HEK293, Fc) is 200 a.a., with molecular weight of 60-90 kDa.

Programmed cell death 1 ligand 2 是一种细胞表面受体也称为 PD-L2, B7-DC 或 CD273。PDCD1LG2 是一种免疫检查点受体配体，在适应性免疫应答中起负性调节作用。PDCD1LG2 与 PD-1 结合可以激活抑制 TCR/ BCR 介导的免疫细胞激活的途径。PDCD1LG2 在免疫耐受和自身免疫中发挥重要作用，PD-L1 和 PDCD1LG2 均可抑制 T 细胞增殖和炎性细胞因子的产生。阻断 PDCD1LG2 会加重实验性自身免疫性脑脊髓炎。PDCD1LG2 在小鼠树突状细胞中触发 IL-12 的产生，导致 T 细胞活化。用 PDCD1LG2 Ig 治疗可导致 T 辅助细胞增殖。PDCD1LG2 在小鼠肿瘤细胞上的表达抑制了细胞毒性 T 细胞介导的免疫反应，可以作为生物标志物或预后指标。

Cynomolgus

HEK293

C-hFc

A4GW30 (L20-P219)

716003  [NCBI]

LFTVTVPKELYIIEHGSNATLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLSLGKALFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNISVPANTSHSRTPEGLYQVTSVLRLKPHPGRNFSCVFWNAQVRELTLASIDLQSQIEPRTHP

60-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.