1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins
  4. B7-DC/PD-L2 B7-DC/CD273
  5. PD-L2 蛋白, Human (HEK293, His)

PD-L2 蛋白, Human (HEK293, His)

目录号: HY-P72492
COA 产品使用指南

PD-L2 蛋白独立于 PDCD1 运行,在 T 细胞增殖和 IFNG 产生中发挥着至关重要的作用。它与 PDCD1 的相互作用抑制增殖和细胞因子的产生。PD-L2 和 PDCD1 之间的相互作用调节免疫反应,影响 T 细胞的激活和功能。这种分子相互作用增加了控制 T 细胞行为的机制的复杂性,凸显了 PD-L2 在免疫调节中的多功能作用。PD-L2 蛋白, Human (HEK293, His) 是重组的 PD-L2 蛋白,由 HEK293 表达,带有 C-His 标签。PD-L2 蛋白, Human (HEK293, His) 全长 200 个氨基酸,分子量为 34-50 kDa。

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重组蛋白定制服务

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥2050 In-stock
50 μg ¥6450 In-stock
100 μg   询价  

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描述

PD-L2 Protein, operating independently of PDCD1, plays a vital role in T-cell proliferation and IFNG production. Its interaction with PDCD1 inhibits proliferation and cytokine production. The interplay between PD-L2 and PDCD1 regulates immune responses, influencing T-cell activation and function. This molecular interaction adds complexity to mechanisms governing T-cell behavior, highlighting PD-L2's versatile role in immune regulation. PD-L2 Protein, Human (HEK293, His) is the recombinant human-derived PD-L2 protein, expressed by HEK293 , with C-His labeled tag. The total length of PD-L2 Protein, Human (HEK293, His) is 200 a.a., with molecular weight of 34-50 kDa.

研究背景

PD-L2 蛋白是对 T 细胞增殖和 IFNG 产生至关重要的共刺激信号的组成部分,以不依赖 PDCD1 的方式运行。然而,它与 PDCD1 的相互作用通过阻碍细胞周期进程和细胞因子产生来抑制 T 细胞增殖。PD-L2 和 PDCD1 之间错综复杂的相互作用强调了其作为调节免疫反应、影响 T 细胞的激活和功能的调节检查点的作用。这种分子相互作用为控制 T 细胞行为的动态机制增加了一层复杂性,凸显了 PD-L2 在免疫调节中的多功能作用。

生物活性

Measured by its binding ability in a functional ELISA. Immobilized human PD-L2 at 2 μg/mL(100 μl/well) can bind human PD-1, the EC50 of human PD-1 is 150-800 ng/mL.

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q9BQ51 (L20-P219)

基因 ID
蛋白结构
N-term
PD-L2 (L20-P219)
Accession # Q9BQ51
His
C-term
同用名
Programmed cell death 1 ligand 2; Pdcd1lg2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; B7-DC; CD273
氨基酸序列

LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHP

分子量

34-50 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4 or PBS, pH 7.4, 5% Trehalose, 5% Mannitol.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PD-L2 Protein, Human (HEK293, His)
目录号:
HY-P72492
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