1. 重组蛋白
  2. Cytokines and Growth Factors
  3. PDGFs & PDGFRs
  4. PDGF
  5. PDGF-B
  6. PDGF-BB 蛋白, Rhesus Macaque (P.pastoris, His)

PDGF-BB 蛋白, Rhesus Macaque (P.pastoris, His)

目录号: HY-P74641
产品使用指南

PDGF-BB 蛋白是 PDGF 家族成员,通过与酪氨酸激酶 PDGF 受体结合,促进细胞增殖、存活和迁移。PDGF-BB 蛋白 可促进肌腱愈合和灵长类动物脊髓半切后的神经调节。PDGF-BB 蛋白, Rhesus Macaque (P.pastoris, His) 是重组的 PDGF-BB 蛋白,由 P. pastoris 表达,带有 N-His 标签。PDGF-BB 蛋白, Rhesus Macaque (P.pastoris, His) 全长 109 个氨基酸,分子量约为 ~14.2 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

PDGF-BB Protein is a member of the PDGF family and promotes cell proliferation, survival, and migration by binding to the tyrosine kinase PDGF receptor. PDGF-BB Protein promotes tendon healing and neuroregulation after spinal cord hemisection in primates. PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) is the recombinant Rhesus Macaque-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) is 109 a.a., with molecular weight of ~14.2 kDa.

研究背景

血小板衍生生长因子 (Platelet derived growth factor, PDGF) 是一种有效的间充质细胞和成骨细胞的有丝分裂原和化学引诱剂,并刺激血管生成分子,在骨再生中发挥重要作用。血小板衍生生长因子 BB 是 PDGF 家族成员,通过与酪氨酸激酶 PDGF 受体结合,促进细胞增殖、存活和迁移。PDGF-BB 对失血性休克有有益作用,这与靶向 CX43 改善血管反应性和血流动力学密切相关。PDGF-BB 通过与PDGFR 结合在下体海绵体平滑肌细胞 (CCSMCs) 中起作用。PDGF-BB 促进肌腱愈合。PDGF-BB 在灵长类动物脊髓半切后的神经调节中发挥重要作用。

种属

Rhesus Macaque

表达系统

P. pastoris

标签

N-His

蛋白编号

XP_001097395 (S82-T190)

基因 ID

703173  [NCBI]

蛋白结构
N-term
His
PDGF-BB (S82-T190)
Accession # XP_001097395
C-term
同用名
Platelet-derived growth factor subunit B; PDGF-2; PDGFB
分子量

Approximately 14.2 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PDGF-BB Protein, Rhesus Macaque (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PDGF-BB Protein, Rhesus Macaque (P.pastoris, His)
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HY-P74641
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