PDGF-BB 蛋白, Mouse (P.pastoris, His)

PDGF-BB, a crucial growth factor, regulates diverse cellular processes, including development, proliferation, migration, survival, and chemotaxis. It is vital for tissue proliferation, blood vessel development, and kidney glomeruli formation. PDGF-BB interacts with PDGFRA, PDGFRB, XLKD1, LRP1, and SORL1, highlighting its versatile cellular involvement. PDGF-BB Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived PDGF-BB protein, expressed by P. pastoris , with N-His labeled tag. The total length of PDGF-BB Protein, Mouse (P.pastoris, His) is 109 a.a., with molecular weight of ~14.2 kDa.

PDGF-BB 是一种重要的生长因子，在调节多种细胞过程中发挥着核心作用，包括胚胎发育、细胞增殖、迁移、存活和趋化性。作为间充质细胞的有效有丝分裂原，PDGF-BB对于各种组织（包括中枢神经系统、皮肤、肺、心脏和胎盘）中周细胞和血管平滑肌细胞的正常增殖和募集是不可或缺的。它对于血管发育和肾小球的形成至关重要，突出了它对组织稳态的多方面贡献。此外，PDGF-BB 在伤口愈合中发挥着关键作用。其复杂的信号传导通过二硫键连接的反向平行同二聚体和与 PDGFA 的反向平行异二聚体的形成来调节。这些动态二聚体与 PDGFRA 和 PDGFRB 同二聚体以及由 PDGFRA 和 PDGFRB 形成的异二聚体进行复杂的相互作用。此外，PDGF-BB 与 XLKD1、LRP1 和 SORL1 相互作用，进一步强调了其在细胞调节中的多功能参与。

Measured by its binding ability in a functional ELISA. Immobilized Human PDGFRB at 2 μg/mL (100 μl/well) can bind Mouse PDGF-B His, the EC₅₀ of Mouse PDGF-B His is 4-24 ng/mL.

Mouse

P. pastoris

N-His

P31240 (S82-T190)

18591  [NCBI]

Approximately 14.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of30 % CAN, 0.1 % TFA.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.