PE-Labeled ACE2 蛋白, Human (HEK293, His)

The ACE2 protein is an important regulator of blood volume and cardiovascular homeostasis. PE-Labeled ACE2 Protein, Human (HEK293, His) is the recombinant human-derived PE-Labeled ACE2 protein, expressed by HEK293, with C-His labeled tag.

ACE2 是肾素-血管紧张素激素系统中不可或缺的反调节羧肽酶，通过复杂地调节血容量和全身血管阻力，在维持心血管稳态中发挥着关键作用。通过其酶活性，ACE2 将血管紧张素 I 转化为血管紧张素 1-9，将血管紧张素 II 转化为血管紧张素 1-7，在心肌细胞中发挥抗肥厚作用，并作为具有抗增殖特性的血管舒张剂。除了在肾素-血管紧张素系统中发挥核心作用外，ACE2 还表现出广泛的酶活性，可裂解各种血管活性肽，例如神经降压素、运动紧张素和去精氨酸缓激肽。此外，ACE2 擅长切割其他生物肽，包括 apelins、酪啡肽和强啡肽 A。值得注意的是，ACE2 的 C 末端与collectrin 同源，协调中性氨基酸转运蛋白 SL6A19 向肠上皮细胞膜的运输，从而调节其表面表达和催化活性。重要的是，ACE2 还充当人类冠状病毒 SARS-CoV、SARS-CoV-2 和 HCoV-NL63 的受体，这表明它与微生物感染途径有关。

Human

HEK293

C-His

Q9BYF1-1 (Q18-S740)

59272

Extracellular Domain

无菌粉末.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 1 year from date of receipt, protect from light. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.