Peroxiredoxin-1 蛋白, Human (P. pastoris, His)

Peroxiredoxin-1 (PRDX1) is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides and plays a crucial role in cellular protection against oxidative stress. It detoxifies peroxide and senses hydrogen peroxide-mediated signaling events. Peroxiredoxin-1 protein, Human (P. pastoris, His) is the recombinant human-derived Peroxiredoxin-1 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of Peroxiredoxin-1 protein, Human (P. pastoris, His) is 199 a.a., with molecular weight of ~22.1 kDa.

Peroxiredoxin-1 (PRDX1) 是一种硫醇特异性过氧化物酶，可作为还原过氧化氢和有机氢过氧化物的催化剂，将其分别转化为水和醇。它在细胞保护免受氧化应激方面的关键作用包括解毒过氧化物并充当过氧化氢介导的信号事件的传感器。PRDX1 还可能有助于生长因子和肿瘤坏死因子-α 启动的信号级联，从而可能影响细胞内 H(2)O(2) 浓度。值得注意的是，PRDX1 表现出减少 GDPD5 中分子内二硫键的能力，调节 GDPD5 驱动有丝分裂后运动神经元分化的能力。这些多方面的功能强调了 PRDX1 在氧化还原信号传导和细胞分化过程中的复杂参与。

Human

P. pastoris

C-6*His

Q06830 (M1-K199)

5052

MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK

Approximately 22.1 KDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.