2. 重组蛋白
  3. Enzymes & Regulators
  4. Isomerases (EC 5)
  5. PGD2 Synthase/PTGDS 蛋白, Mouse (HEK293, His)

PGD2 Synthase/PTGDS 蛋白, Mouse (HEK293, His)

目录号: HY-P73710
产品使用指南

PGD2 合酶/PTGDS 蛋白是一种酶，参与前列腺素 D2 (PGD2) 的合成。PGD2 合酶/PTGDS 蛋白的失调与过敏性疾病和炎症有关。靶向 PGD2 合酶/PTGDS 蛋白可能通过调节 PGD2 水平、减少过敏反应和控制炎症相关疾病，为这些疾病提供潜在的治疗干预。PGD2 Synthase/PTGDS 蛋白, Mouse (HEK293, His) 是重组的 PGD2 合酶/PTGDS 蛋白，由 HEK293 表达，带有 C-His 标签。PGD2 Synthase/PTGDS 蛋白, Mouse (HEK293, His) 全长 189 个氨基酸，分子量约为 ~19.9 kDa。

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描述

PGD2 Synthase/PTGDS Protein, an enzyme, is involved in the synthesis of prostaglandin D2 (PGD2). Dysregulation of PGD2 Synthase/PTGDS Protein has been linked to allergic diseases and inflammation. Targeting PGD2 Synthase/PTGDS Protein may provide potential therapeutic interventions in these conditions by modulating PGD2 levels, reducing allergic responses, and managing inflammation-related disorders. PGD2 Synthase/PTGDS Protein, Mouse (HEK293, His) is the recombinant mouse-derived PGD2 Synthase/PTGDS protein, expressed by HEK293, with C-His labeled tag. The total length of PGD2 Synthase/PTGDS Protein, Mouse (HEK293, His) is 189 a.a., with molecular weight of ~19.9 kDa.
研究背景

PGD2 合酶/PTGDS 蛋白充当 PGH2 转化为 PGD2 的催化剂，PGD2 是一种前列腺素，在平滑肌收缩/松弛中发挥着至关重要的作用，并可作为血小板聚集的有效抑制剂。它与各种中枢神经系统 (CNS) 功能有关，包括镇静、NREM 睡眠、PGE2 诱导的异常性疼痛，并可能充当少突胶质细胞的抗凋亡因子。此外，这种蛋白质与小的非底物亲脂性分子（例如胆绿素、胆红素、视黄醛、视黄酸和甲状腺激素）结合，可能充当有害疏水化合物的清除剂，并充当类维生素A和甲状腺激素的分泌转运蛋白。它可能参与血脑、血视网膜、血房水和血睾屏障的发育和维持。此外，它在中枢神经系统和男性生殖系统的成熟和维持中发挥着重要作用。它还通过参与 PLA2G3 依赖性途径参与肥大细胞的成熟，其中未成熟肥大细胞分泌的 PLA2G3 作用于 PTGDS 上游的邻近成纤维细胞，导致 PGD2 的合成，最终促进肥大细胞成熟和脱颗粒通过 PTGDR。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

O09114 (M1-E189)
基因 ID

19215  [NCBI]
蛋白结构
N-term
PTGDS (M1-E189)
Accession # O09114
His
C-term
同用名
Prostaglandin-H2 D-isomerase; L-PGDS; PGDS2; PTGDS
分子量

Approximately 19.9 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PGD2 Synthase/PTGDS Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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