PGLYRP1/PGRP-S 蛋白, Mouse (HEK293, Fc)

PGLYRP1/PGRP-S Protein plays a vital role in the innate immune response. It recognizes bacterial peptidoglycan and activates antimicrobial defense mechanisms. PGLYRP1/PGRP-S Protein interacts with other immune molecules, enhancing immune responses against bacterial infections. Understanding its functions can aid in developing strategies to combat bacterial pathogens. PGLYRP1/PGRP-S Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PGLYRP1/PGRP-S Protein, Mouse (HEK293, Fc) is 164 a.a., with molecular weight of 50-55 kDa.

PGLYRP1/PGRP-S 是一种先天免疫蛋白，在抗菌和抗肿瘤防御系统中发挥多方面作用。作为模式受体，它与革兰氏阳性菌的胞壁肽聚糖 (PGN) 结合，从而发挥杀菌活性。此外，它与热休克蛋白 HSPA1A 形成等摩尔复合物，通过激活 TNFR1 受体，在肿瘤细胞系中通过细胞凋亡和坏死性凋亡触发程序性细胞死亡。它与Ca(2+)结合蛋白S100A4协同作用，作为化学引诱剂，诱导淋巴细胞运动并激活淋巴细胞以消除病毒感染的细胞和肿瘤细胞。单核细胞表面细胞毒性的诱导需要与 TREM1 受体相互作用。该蛋白呈现出通过二硫键连接的同二聚体结构，并与 HSPA1A 和 HSPBP1 相互作用，调节其细胞毒性活性。这些多功能功能强调了 PGLYRP1/PGRP-S 在免疫反应和防御机制中的关键参与。

Mouse

HEK293

C-hFc

O88593 (F19-E182)

21946  [NCBI]

50-55 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22 μm filtered solution of PBS, 10% glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.