PIGR 蛋白, Human (G365S, HEK293, His)

PIGR Protein plays a crucial role in mediating the selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells, essential for mucosal immunity. Binding these immunoglobulins at the basolateral surface, PIGR forms a complex transported across the cell and secreted apically. Through N-linked glycans, PIGR anchors secretory IgA (sIgA) to mucosal surfaces, neutralizing pathogens. In its free form, PIGR also acts as a microbial scavenger, contributing to the defense against infections. PIGR Protein, Human (G365S, HEK293, His) is the recombinant human-derived PIGR protein, expressed by HEK293 , with C-His labeled tag and G365S mutation. The total length of PIGR Protein, Human (G365S, HEK293, His) is 638 a.a., with molecular weight of 80-90 kDa.

PIGR 蛋白在介导聚合 IgA 和 IgM 跨粘膜上皮细胞的选择性转胞吞作用中发挥着至关重要的作用，协调粘膜免疫所必需的过程。该蛋白与上皮细胞基底外侧表面的聚合 IgA 和 IgM 结合，形成复合物，随后转运穿过细胞并在顶端表面分泌。在此转运过程中，发生裂解事件，将细胞外成分（称为分泌成分）与跨膜片段分离。 PIGR 通过其 N 连接聚糖确保分泌型 IgA (sIgA) 分子锚定在上皮表面的粘液上，这是中和细胞外病原体的关键机制。游离形式的 PIGR 还可以充当非特异性微生物清道夫，在防止病原体与上皮细胞相互作用方面发挥作用，并有助于更广泛地防御潜在感染。

Human

HEK293

C-His

P01833 (M1-R638, G365S)

5284  [NCBI]

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.