PILR-alpha 蛋白, Human (178a.a, HEK293, His)

Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing member of the paired receptor which consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction such as SH1 through dephosphorylation of signaling molecules. PILR-alpha Protein, Human (178a.a, HEK293, His) is the recombinant human-derived PILR-alpha protein, expressed by HEK293 , with C-His labeled tag.

配对免疫球蛋白样 2 型受体 α (PILRA) 是一种免疫受体酪氨酸基抑制基序 (ITIM) 成员携带的配对受体，由高度相关的激活受体和抑制受体组成，广泛参与免疫系统的调节。PILRA 被认为是一种细胞信号抑制受体，通过配体的 SH2 结构域募集细胞质磷酸酶，如 PTPN6/SHP-1 和 PTPN11/SHP-2，通过信号分子的去磷酸化阻断信号转导，而 SHP-1 介导的蛋白酪氨酸残基的去磷酸化是调节几种细胞信号通路的核心。PLPRA 是 PIANP 的受体，也是单纯疱疹病毒 1 的进入共受体^[1][2][3]。

Immobilized Human PILRA, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-PILRA Antibody, Rabbit IgG Tag with the EC₅₀ of ≤8.9 ng/mL determined by ELISA.

Human

HEK293

C-His

Q9UKJ1-1 (Q20-A197)

29992  [NCBI]

QPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETA

40-50 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.