PRDX6 蛋白, Human (His)

The PRDX6 protein is a thiol-specific peroxidase that plays a crucial role in cellular defense against oxidative stress. It catalyzes the reduction of hydrogen peroxide and various organic hydroperoxides to water and alcohols. PRDX6 Protein, Human (His) is the recombinant human-derived PRDX6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PRDX6 Protein, Human (His) is 224 a.a., with molecular weight of 30-33 kDa.

PRDX6 是一种硫醇特异性过氧化物酶，通过催化过氧化氢和各种有机氢过氧化物分别还原为水和醇，在细胞防御氧化应激方面发挥着至关重要的作用。这种多功能酶具有还原 H(2)O(2) 以及短链有机物、脂肪酸和磷脂氢过氧化物的能力。此外，PRDX6 具有磷脂酶活性，使其能够通过过氧化物酶活性还原磷脂的氧化 sn-2 脂肪酰基，或通过磷脂酶活性水解磷脂的 sn-2 酯键。这些功能取决于其在酸性 pH 下与磷脂的结合以及在胞质 pH 下与氧化磷脂的结合。除了其过氧化物酶活性外，PRDX6 在磷脂稳态中发挥着关键作用，并作为酰基辅酶 A 依赖性溶血磷脂酰基转移酶，促进溶血磷脂酰胆碱 (LPC) 转化为磷脂酰胆碱 (PC)。该酶表现出明显偏好 LPC 作为溶血磷脂和棕榈酰 CoA 作为脂肪酰基底物。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

P30041 (M1-P224)

9588  [NCBI]

MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

30-33kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.