1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens Receptor Proteins
  3. Inhibitory checkpoint molecules Stimulatory immune checkpoint molecules NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. PVR/CD155
  6. PVR/CD155 蛋白, Human (HEK 293, His)

PVR/CD155 蛋白, Human (HEK 293, His)

目录号: HY-P70807
COA 产品使用指南

PVR/CD155 蛋白, Human (HEK 293, His)是一种在 HEK 293 细胞中表达的,N 末端有 His 标签的重组人PVR。PVR, Human 在癌细胞的侵袭和迁移中起作用。

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规格 价格 是否有货 数量
10 μg ¥1200 In-stock
50 μg ¥3600 In-stock
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250 μg   询价  

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描述

PVR/CD155 Protein, Human (HEK 293, His) is a recombinant Human PVR expressed in HEK 293 cells with a His tag at the N-terminus. PVR, Human plays a role in cancer cell invasion and migration[1][2].

研究背景

PVR/CD155, also known as the human poliovirus receptor (PVR) is a member of the subfamily of immunoglobulin (Ig)-like molecules composed of an N-terminal variable-like, followed by two constant-like extracellular domains, a single transmembrane region and a cytoplasmic tail of variable length. CD155 binds the extracellular matrix protein vitronectin thereby mediating cell to matrix contacts. The cytoplasmic tail of CD155 interacts with the μ1B subunit of the clathrin adaptor complex resulting in directed transport of CD155 in polarized epithelial cells[1][2].

生物活性

Immobilized Human TIGIT-Fc at 5μg/mL (100 μL/well) can bind PVR/CD155 Protein, Human (HEK 293, His) and the ED50 is 10-30 ug/mL.

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

NP_006496 (W21-N343)

基因 ID

5817  [NCBI]

同用名
Poliovirus Receptor; Nectin-Like Protein 5; NECL-5; CD155; PVR; PVS
氨基酸序列

WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRN

分子量

Approximately 58.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

Solution

组分

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

保存条件 & 期限

Stored at -80°C. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料
参考文献
  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PVR/CD155 Protein, Human (HEK 293, His)
目录号:
HY-P70807
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