RCN3 蛋白, Human (HEK293, His)

The RCN3 protein is a possible molecular chaperone that contributes to endoplasmic reticulum protein biosynthesis and transport. RCN3 is critical for pulmonary surfactant homeostasis and is required for the correct biosynthesis and transport of SP-A, SP-D, and ABCA3. RCN3 Protein, Human (HEK293, His) is the recombinant human-derived RCN3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RCN3 Protein, Human (HEK293, His) is 308 a.a., with molecular weight of ~43.0 kDa.

RCN3 蛋白是一种可能的分子伴侣，有助于蛋白质生物合成和内质网内的运输。它是肺表面活性剂相关蛋白 A/SP-A 和 D/SP-D 以及脂质转运蛋白 ABCA3 的正确生物合成和转运所必需的。RCN3 通过内质网相关蛋白降解途径调节这些蛋白的表达和降解，在维持肺表面活性物质稳态中发挥着至关重要的作用。此外，它还通过负调节 I 型和 III 型胶原蛋白的分泌来表现出抗纤维化活性。已知 RCN3 会与未成熟的 PCSK6 短暂结合，并参与其成熟和分泌。

Human

HEK293

C-6*His

Q96D15 (K21-L328)

57333  [NCBI]

KPSPDAGPHGQGRVHQAAPLSDAPHDDAHGNFQYDHEAFLGREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSAAWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTRHHDEL

Approximately 43.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.