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  3. RGM-C 蛋白, Human (HEK293, His)

RGM-C 蛋白, Human (HEK293, His)

目录号: HY-P78028
产品使用指南

RGM-C 蛋白是一种 BMP 辅助受体,可重要地调节 BMP 信号传导并调节铁调素 (HAMP) 表达,从而影响铁稳态。它与 BMP2、BMP4、BMP6、BMPR1B 和 TMPRSS6 相互作用,形成一个分子网络,共同介导 BMP 相关信号通路和铁调节。RGM-C 蛋白, Human (HEK293, His) 是重组的 RGM-C 蛋白,由 HEK293 表达,带有 C-His 标签。RGM-C 蛋白, Human (HEK293, His) 全长 361 个氨基酸,分子量分别为 55-60 kDa & 30-40 kDa & 20-25 kDa。

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描述

RGM-C Protein, a BMP coreceptor, crucially modulates BMP signaling and regulates hepcidin (HAMP) expression, impacting iron homeostasis. It interacts with BMP2, BMP4, BMP6, BMPR1B, and TMPRSS6, forming a molecular network that collectively mediates BMP-related signaling pathways and iron regulation. RGM-C Protein, Human (HEK293, His) is the recombinant human-derived RGM-C protein, expressed by HEK293, with C-His labeled tag. The total length of RGM-C Protein, Human (HEK293, His) is 361 a.a., with molecular weight of 55-60 kDa & 30-40 kDa & 20-25 kDa, respectively.

研究背景

RGM-C 作为骨形态发生蛋白 (BMP) 辅助受体发挥作用,有助于 BMP 信号传导的调节,并在铁调素 (HAMP) 表达的调节中发挥关键作用,从而影响铁稳态。该蛋白与 BMP2、BMP4、BMP6、BMPR1B 和 TMPRSS6 相互作用,形成分子关联网络,共同发挥其在介导 BMP 相关信号传导途径和铁调节中的作用。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

Q6ZVN8-1 (Gln33-Asp393)

基因 ID
蛋白结构
N-term
RGM-C (Gln33-Asp393)
Accession # Q6ZVN8-1
His
C-term
同用名
Hemojuvelin; Rgmc; DL-M; HFE2; HFE2AMGC23953; HJV; JH; RGMC; RGM-C
分子量

55-60 kDa&30-40 kDa&20-25 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

RGM-C Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
RGM-C Protein, Human (HEK293, His)
目录号:
HY-P78028
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