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  3. S100A8 蛋白, Rat (His)

S100A8 蛋白, Rat (His)

目录号: HY-P71275
COA 产品使用指南

S100A8 蛋白在炎症中充当危险信号,通过与 Toll 样受体 4 (TLR4) 和晚期糖基化终产物受体 (AGER) 等受体结合来激活先天免疫细胞。这会触发增强促炎症反应的信号通路。S100A8 蛋白, Rat (His) 是重组的 S100A8 蛋白,由 E. coli 表达,带有 C-6*His 标签。S100A8 蛋白, Rat (His) 全长 89 个氨基酸,分子量约为 ~13.0 kDa。

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规格 价格 是否有货 数量
10 μg ¥1200 In-stock
50 μg ¥3600 In-stock
100 μg   询价  

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描述

S100A8 protein functions as a danger signal in inflammation, activating innate immune cells by binding to receptors like Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). This triggers signaling pathways that enhance the pro-inflammatory response. S100A8 Protein, Rat (His) is the recombinant rat-derived S100A8 protein, expressed by E. coli , with C-6*His labeled tag. The total length of S100A8 Protein, Rat (His) is 89 a.a., with molecular weight of ~13.0 kDa.

研究背景

S100A8 是一种在炎症和免疫反应中发挥作用的分子。它充当危险信号,并通过与 Toll 样受体 4 (TLR4) 和晚期糖基化终产物受体 (AGER) 等受体结合来刺激先天免疫细胞。这种结合激活信号通路,放大促炎症反应。

种属

Rat

表达系统

E. coli

标签

C-6*His

蛋白编号

P50115 (M1-E89)

基因 ID

116547  [NCBI]

蛋白结构
N-term
S100A8 (M1-E89)
Accession # P50115
6*His
C-term
同用名
Protein S100-A8; S100a8; Calgranulin-A; Chemotactic cytokine CP-10; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; Pro-inflammatory S100 cytokine; S100 calcium-binding protein A8; Caga; Mrp8
氨基酸序列

MATELEKALSNVIEVYHNYSGIKGNHHALYRDDFRKMVTTECPQFVQNKNTESLFKELDVNSDNAINFEEFLVLVIRVGVAAHKDSHKE

分子量

Approximately 13.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

S100A8 Protein, Rat (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
S100A8 Protein, Rat (His)
目录号:
HY-P71275
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