Serpin A7 蛋白, Mouse (HEK293, His)

Serpin A7 protein binds hormones and inhibits serine-type endopeptidase activity. It is involved in negative regulation of endopeptidase activity, response to vitamin A, and thyroid hormone transport. It is located in the extracellular region and is active in the extracellular space. Serpin A7 is orthologous to human SERPINA7 and is expressed primarily in liver E18, liver E14.5, and two other tissues. Serpin A7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A7 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A7 Protein, Mouse (HEK293, His) is 398 a.a., with molecular weight of 55-60 kDa.

Serpin A7 蛋白预计具有激素结合活性以及丝氨酸型内肽酶抑制剂活性。据信它参与多种过程，包括肽链内切酶活性的负调节、对维生素 A 的反应和甲状腺激素转运。预计该蛋白质位于细胞外区域并在细胞外空间中活跃。它与人类 SERPINA7（丝氨酸蛋白酶抑制剂家族 A 成员 7）是直系同源的。就表达而言，它在肝脏E18、肝脏E14.5和其他两种组织中表现出偏向表达。

Immobilized Thyroxine-BSA Conjugate at 2.5 μg/mL (100 μL/well) can bind Biotinylated Serpin A7. The ED₅₀ for this effect is 1.317 µg/mL.

Mouse

HEK293

C-His

NP_808588.3 (A29-Q426)

331535  [NCBI]

APHNSSEGKVTTCHLPQQNATLYKMPSINADFAFSLYRRLSVENPDLNIFFSPVSISVALAMLSFGSGSSTQTQILEVLGFNLTDTPVTELQQGFQHLICSLNFPKNELELQMGNAVFIGQQLKPLAKFLDDVKTLYETEVFSTDFSNVSAAQHKINSYVEKQTKGKIVGLIQGLKLNIIMILVNYIHFRAQWANPFRVSKTEESSNFSVDKSTTVQVPMMHQLEQYYHYVDMELNCTVLQMDYSENALALFVLPKEGHMEWVEAAMSSKTLKKWNYLLQKGWVELFVPKFSISATYDLGSTLQKMGMRDAFAESADFPGITEDSGLKLSYAFHKAVLHIGEEGTKEGASPEVGSLDQQEVPPLHPVIRLDRAFLLMILEKRTRSVLFLGKLVNPTKQ

Approximately 60-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.