Serpin A8/Angiotensinogen 蛋白, Rat (HEK293, His)

Serpin A8 (or angiotensinogen) is a key regulator of the renin-angiotensin system, affecting blood pressure, fluid and electrolyte balance. As a vasoconstrictor, it directly affects vascular smooth muscle and affects myocardial contractility and heart rate through the sympathetic nervous system. Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is 453 a.a., with molecular weight of 58-75 kDa.

Serpin A8，也称为血管紧张素原，是肾素-血管紧张素系统 (RAS) 复杂网络中的重要组成部分，是血压、体液和电解质稳态的有效调节剂。这种多方面的蛋白质对各种生理过程产生影响。它直接影响血管平滑肌，起到强大的血管收缩剂的作用，通过与交感神经系统的相互作用影响心肌收缩力和心率。此外，血管紧张素原通过刺激肾上腺皮质球状带细胞合成和释放醛固酮来调节钠和水的吸收，从而在肾功能中发挥至关重要的作用。这些不同的作用是通过其与血管紧张素受体 AGTR1 和 AGTR2 的结合介导的。除了在 RAS 中的作用之外，血管紧张素原还表现出其他相互作用，例如与 DEAR/FBXW7-AS1 受体结合，扩大其在细胞信号传导网络中的参与。

Rat

HEK293

C-10*His

P01015 (D25-V477)

24179  [NCBI]

DRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV

Approximately 58-75 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.