Serum Albumin/ALB 蛋白, Cynomolgus (P.pastoris, His)

Serum albumin (ALB) protein binds a variety of substances, including water, calcium, sodium, potassium, fatty acids, hormones, bilirubin, and drugs. It regulates blood osmolality and transports zinc, calcium and magnesium. Serum Albumin/ALB Protein, Cynomolgus (P.pastoris, His) is the recombinant cynomolgus-derived Serum Albumin/ALB protein, expressed by P. pastoris , with N-His labeled tag. The total length of Serum Albumin/ALB Protein, Cynomolgus (P.pastoris, His) is 584 a.a., with molecular weight of ~68.0 kDa.

血清白蛋白 (ALB) 蛋白具有多种作用，包括结合水、钙、钠、钾、脂肪酸、激素、胆红素和药物。其主要功能涉及调节血液的胶体渗透压。ALB 是血浆中锌的主要转运蛋白，结合约 80% 的血浆锌。它还作为钙和镁的重要转运蛋白，结合血浆中大约 45% 的循环钙和镁。ALB 可能拥有多个钙结合位点，并且还可以以非特异性方式结合钙。残基 Asp-273 处锌和钙之间存在共享结合位点，表明血液中锌和钙转运之间存在潜在的相互作用和通讯，其中锌表现出更高的亲和力，其次是钙和镁。ALB 还与细菌铁载体肠杆菌素相互作用，阻碍肠杆菌介导的大肠杆菌从铁转铁蛋白中摄取铁，从而限制铁的利用和大肠杆菌等肠道细菌的生长。然而，它不会阻碍细菌铁载体需氧菌素对铁的吸收。ALB 与 FCGRT 相互作用以调节其稳态，并与 TASOR 相互作用。在血浆中，ALB 与发色团结合的 α-1-微球蛋白形成共价连接的复合物，但这种相互作用并不妨碍脂肪酸与 ALB 的结合。

Cynomolgus

P. pastoris

N-His

A2V9Z4 (25D-608A)

102130757  [NCBI]

DTHKSEVAHRFKDLGEEHFKGLVLVAFSQYLQQCPFEEHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPPLVRPEVDVMCTAFHDNEATFLKKYLYEVARRHPYFYAPELLFFAARYKAAFAECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGDRAFKAWAVARLSQKFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYMCENQDSISSKLKECCDKPLLEKSHCLAEVENDEMPADLPSLAADYVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVMLLLRLAKAYEATLEKCCAAADPHECYAKVFDEFQPLVEEPQNLVKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGAKCCKLPEAKRMPCAEDYLSVVLNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALELDEAYVPKAFNAETFTFHADMCTLSEKEKQVKKQTALVELVKHKPKATKEQLKGVMDNFAAFVEKCCKADDKEACFAEEGPKFVAASQAALA

Approximately 68.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in Tris-based buffer, 50% glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.