SGSH 蛋白, Human (HEK293, His)

SGSH (N-sulfoglucosamine sulfohydrolase) plays a key role in catalyzing specific steps in the lysosomal degradation of heparan sulfate. Through its enzymatic activity, SGSH contributes to the breakdown of heparan sulfate molecules, an important component of the extracellular matrix and cell surfaces. SGSH Protein, Human (HEK293, His) is the recombinant human-derived SGSH protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SGSH Protein, Human (HEK293, His) is 482 a.a., with molecular weight of ~63.0 kDa.

SGSH（即 N-磺基葡萄糖胺磺基水解酶）在催化溶酶体硫酸乙酰肝素降解过程中的特定步骤中发挥着关键作用。通过其酶活性，SGSH 有助于硫酸乙酰肝素分子的分解，硫酸乙酰肝素分子是细胞外基质和细胞表面的重要组成部分。这种降解过程对于维持细胞稳态和各种组织和器官的正常功能至关重要。了解 SGSH 介导的溶酶体硫酸乙酰肝素降解的精确机制和调节，可以深入了解与硫酸乙酰肝素积累相关的溶酶体贮积症的发病机制和潜在治疗靶点。

Human

HEK293

C-6*His

P51688 (R21-L502)

6448  [NCBI]

RPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNEL

Approximately 63.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.