1. 重组蛋白
  2. CD Antigens Receptor Proteins Biotinylated Proteins
  3. Dendritic Cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. SIRP alpha/CD172a Immunoglobulin-like Cell Adhesion Molecules
  5. Signal Regulatory Protein α
  6. SIRP alpha V4/CD172a 蛋白, Human (HEK293, His-Avi)

SIRP alpha V4/CD172a 蛋白, Human (HEK293, His-Avi)

目录号: HY-P77843
产品使用指南

SIRP α V4/CD172a 蛋白是 CD47 的免疫球蛋白样细胞表面受体,充当对接蛋白,促进 PTPN6、PTPN11 和其他伙伴易位到质膜。它支持小脑神经元的粘附,促进神经突生长,并促进神经胶质细胞附着。它参与负调节,调节受体酪氨酸激酶偶联反应、吞噬作用、肥大细胞激活和树突细胞激活。 CD47 结合可防止树突状细胞成熟、抑制细胞因子产生并限制新世界沙粒病毒感染。 SIRP α V4/CD172a 还参与 ROS 信号传导,与 THBS1 和各种蛋白质相互作用。SIRP alpha V4/CD172a 蛋白, Human (HEK293, His-Avi) 是重组的 SIRP alpha V4/CD172a 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签和 E33G,L44S,T50S,T52I 突变。SIRP alpha V4/CD172a 蛋白, Human (HEK293, His-Avi) 全长 340 个氨基酸,分子量为 50-70 kDa。

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描述

SIRP alpha V4/CD172a Protein, an immunoglobulin-like cell surface receptor for CD47, acts as a docking protein, facilitating the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports adhesion of cerebellar neurons, promotes neurite outgrowth, and facilitates glial cell attachment. Engaging in negative regulation, it modulates receptor tyrosine kinase-coupled responses, phagocytosis, mast cell activation, and dendritic cell activation. CD47 binding prevents dendritic cell maturation, inhibits cytokine production, and limits new world arenavirus infection. SIRP alpha V4/CD172a also participates in ROS signaling, interacting with THBS1 and various proteins. SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP alpha V4/CD172a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and E33G, L44S, T50S, T52I, R54H mutation. The total length of SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) is 340 a.a., with molecular weight of 50-70 kDa.

研究背景

SIRP α V4/CD172a 蛋白是一种 CD47 的免疫球蛋白样细胞表面受体,充当对接蛋白,促进 PTPN6、PTPN11 和其他结合伴侣从细胞质易位到质膜。该受体有助于多种细胞过程,包括支持小脑神经元的粘附、促进神经突生长和促进神经胶质细胞附着。 SIRP α V4/CD172a 在突触发生和突触功能期间的细胞内信号传导中具有潜在作用,还参与由细胞粘附、生长因子或胰岛素触发的受体酪氨酸激酶偶联反应的负调节。此外,它介导吞噬作用、肥大细胞激活和树突细胞激活的负调节。值得注意的是,CD47 结合可防止未成熟树突细胞的成熟,并抑制成熟树突细胞产生细胞因子。 SIRP alpha V4/CD172a 在抗病毒免疫中发挥着重要作用,通过减少病毒内化来限制新世界沙粒病毒感染。作为 THBS1 的受体,它在与 THBS1 相互作用后参与非吞噬细胞中的 ROS 信号传导,刺激 NADPH 氧化酶衍生的 ROS 产生。该受体参与各种蛋白质相互作用,包括与 PTPN11、GRB2、FGR、JAK2、SCAP1、SCAP2、FYB1、PTK2B 和 TRIM2 结合。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P78324 (E31-R370, E33G, L44S, T50S, T52I, R54H)

基因 ID
蛋白结构
N-term
CD172a (E31-R370, E33G, L44S, T50S, T52I, R54H)
Accession # P78324
His-Avi
C-term
同用名
CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3
分子量

50-70 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi)
目录号:
HY-P77843
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