SLC11A2 蛋白, Human (Sf9, His, MBP, FLAG)

The SLC11A2 protein is a proton-coupled metal ion symporter that selectively transports divalent metal cations, including Cd(2+), Fe(2+), Co(2+), Mn(2+), and less Significant Zn(2+), Ni(2+), VO(2+), the stoichiometric ratio of protons and metal ions is 1:1. It is critical for iron homeostasis, regulating intestinal Fe(2+) absorption, transporting TF-associated endosomal Fe(2+), and promoting Fe(2+) and Mn(2+) entry into mitochondria. SLC11A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC11A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC11A2 Protein, Human (Sf9, His, MBP, FLAG) is 567 a.a., .

SLC11A2 蛋白是一种质子耦合金属离子同向转运蛋白，其质子与金属离子化学计量比为 1:1，选择性转运具有不同亲和力的各种二价金属阳离子，包括 Cd(2+)、Fe(2+)、Co( 2+)、Mn(2+)，以及次要的 Zn(2+)、Ni(2+)、VO(2+)。它通过调节肠道对膳食 Fe(2+) 的吸收并促进 TF 相关内体 Fe(2+) 在红系前体细胞和其他细胞中的转运，在维持铁稳态方面发挥着至关重要的作用。此外，SLC11A2 促进 Fe(2+) 和 Mn(2+) 离子进入线粒体，表明其参与促进线粒体血红素合成、铁硫簇生物发生和抗氧化防御。值得注意的是，该蛋白质表现出介导质子或金属离子的非耦合通量的能力，展示了其多功能的运输能力。

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

P49281 (V2-R568)

4891

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.