SLC22A12 蛋白, Human (HEK293)

SLC22A12 Protein, Human (HEK293) is the recombinant human-derived SLC22A12, expressed by HEK293 , with tag Free labeled tag. ,

SLC22A12 是一种电中性逆向转运蛋白，负责将尿酸转运至近端肾小管细胞的顶膜，并与单价有机或无机阴离子进行交换。它参与尿酸的肾脏重吸收，有助于维持血液中的尿酸水平。该蛋白介导尿酸摄取，通过与有机阴离子如 (S)-lactate 和 nicotinate 以及无机阴离子 Cl(-) 进行交换。其他无机阴离子如 Br(-)、I(-) 和 NO3(-) 也可能作为交换尿酸的抗衡阴离子。此外，SLC22A12 还介导 orotate 的肾小管摄取，与 nicotinate 外流耦合，并在较小程度上与 lactate 外流耦合，因此可能在 orotate 的肾脏重吸收中发挥作用。Orotate 的转运是 Cl(-) 依赖性的。by similar

Human

HEK293

Tag Free

Q96S37-1 (A2-F553) with several site mutations

116085

Partial

Approximately 60.7 kDa

Greater than 85% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.003% (w/v) LMNG, 0.0003% (w/v) CHS.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.