SPINK2 蛋白, Human (HEK293, Fc)

SPINK2, a robust acrosin inhibitor, is vital for normal spermiogenesis, preventing premature activation of proacrosin and other proteases to avoid spermiogenesis defects. It likely regulates germ cell apoptosis mediated by serine proteases and displays inhibitory activity against trypsin, indicating involvement in diverse serine protease-dependent processes. SPINK2 Protein, Human (HEK293, Fc) is the recombinant human-derived SPINK2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of SPINK2 Protein, Human (HEK293, Fc) is 61 a.a., with molecular weight of ~33.6-38 kDa.

SPINK2 是顶体素的有效抑制剂，在确保正常的精子发生中发挥着至关重要的作用。其主要功能可能是阻止顶体蛋白原和其他蛋白酶的过早激活，从而防止可能导致精子发生缺陷的事件的发生。SPINK2 可能还参与丝氨酸蛋白酶介导的生殖细胞凋亡的调节。除了顶体酶抑制作用之外，SPINK2 还表现出对胰蛋白酶的抑制活性，表明它参与调节各种丝氨酸蛋白酶依赖性过程。

Data is not available.

Human

HEK293

C-hFc

P20155/NP_066937.1 (Q24-C84)

6691  [NCBI]

QFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC

Approximately 33.6-38 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.