1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins
  4. SR-BI/CD36 TREM-1/CD354
  5. SR-BI/SCARB1 蛋白, Human (HEK293, Fc)

SR-BI/SCARB1 蛋白, Human (HEK293, Fc)

目录号: HY-P76656
产品使用指南

SR-BI/SCARB1蛋白是一种多功能受体,可结合多种配体,包括磷脂、胆固醇酯、脂蛋白、磷脂酰丝氨酸和凋亡细胞。作为 HDL 受体,它至关重要地介导选择性胆固醇醚摄取和 HDL 依赖性胆固醇流出。SR-BI/SCARB1 蛋白, Human (HEK293, Fc) 是重组的 SR-BI/SCARB1 蛋白,由 HEK293 表达,带有 C-hFc 标签。SR-BI/SCARB1 蛋白, Human (HEK293, Fc) 全长 411 个氨基酸,分子量约为 ~73.4 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

The SR-BI/SCARB1 protein is a multifunctional receptor that binds a variety of ligands, including phospholipids, cholesteryl esters, lipoproteins, phosphatidylserine, and apoptotic cells. As an HDL receptor, it crucially mediates selective cholesterol ether uptake and HDL-dependent cholesterol efflux. SR-BI/SCARB1 Protein, Human (HEK293, Fc) is the recombinant human-derived SR-BI/SCARB1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SR-BI/SCARB1 Protein, Human (HEK293, Fc) is 411 a.a., with molecular weight of ~73.4 kDa.

研究背景

SR-BI/SCARB1 蛋白作为一种多功能受体,可与多种配体结合,包括磷脂、胆固醇酯、脂蛋白、磷脂酰丝氨酸和凋亡细胞。作为 HDL 受体,它在胆固醇醚的选择性摄取和 HDL 依赖性胆固醇流出中发挥着至关重要的作用。此外,SR-BI 促进细胞表面和含有 apoB 的脂蛋白之间游离和酯化胆固醇的交换,尽管效率低于 HDL。它通过磷脂酰丝氨酸结合活性介导参与凋亡细胞的吞噬作用,为其功能库增添了另一层。在微生物感染的情况下,SR-BI 在肝细胞中充当丙型肝炎病毒的受体,促进其进入细胞,而与病毒分离株基因型无关。不同的配体相互作用以及在胆固醇稳态、凋亡细胞清除和病毒感染中的作用凸显了 SR-BI/SCARB1 作为细胞过程中的多功能参与者。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

Q8WTV0-1/NP_001076428.1 (P33-Y443)

基因 ID

949  [NCBI]

蛋白结构
N-term
SR-BI (P33-Y443)
Accession # Q8WTV0
hFc
C-term
同用名
Scavenger receptor class B member 1; SRB1; CLA-1; CD36; CD36L1
分子量

Approximately 73.4 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
SR-BI/SCARB1 Protein, Human (HEK293, Fc)
目录号:
HY-P76656
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