Stomatin/STOM 蛋白, Human (HEK293, Fc)

Stomatin/STOM protein is a key regulator of ion channel activity, affecting ASIC2 and ASIC3 to form unique banana-shaped homodimers and higher-order homo-oligomers. It interacts with ASIC1, ASIC2, and ASIC3 to regulate their functions, and forms a complex with LANCL1 to positively regulate SLC4A1 activity. Stomatin/STOM Protein, Human (HEK293, Fc) is the recombinant human-derived Stomatin/STOM protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Stomatin/STOM Protein, Human (HEK293, Fc) is 234 a.a., with molecular weight of ~75 KDa.

Stomatin/STOM 蛋白是离子通道活性和跨膜离子转运的关键调节因子。它对 ASIC2 和 ASIC3 通道活性产生影响，形成同源二聚体和高阶同源寡聚体，呈现出独特的香蕉形结构。Stomatin/STOM 与 ASIC1、ASIC2 和 ASIC3 相互作用，表明它参与调节它们的功能。此外，它与 LANCL1 形成复合物，并且它与 SLC2A1 的相互作用正向调节 SLC4A1 活性。Stomatin/STOM 也是涉及 SLC40A1、SLC14A1、SLC29A1 和 AQP1 的大型复合物的一部分，进一步强调了其在复杂的细胞过程中的作用。此外，它与 STOML1 的相互作用表明在将 STOM 从质膜重新分配到晚期内体中具有潜在作用，为其调节功能增加了另一层。

Human

HEK293

C-mFc

P27105 (K55-G288)

2040  [NCBI]

KIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG

Approximately 75 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.