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SUMO1 蛋白, Human (His)

目录号: HY-P70997
COA 产品使用指南

SUMO1 蛋白是 SUMO (小泛素样修饰剂) 蛋白家族的成员。SUMO1 作为翻译后修饰系统的一部分与目标蛋白结合。它参与多种细胞过程,如核运输、转录调节、细胞凋亡和蛋白质稳定性。SUMO1 还通过非共价相互作用调节多种蛋白质的功能。SUMO1 蛋白, Human (His) 是重组的 SUMO1 蛋白,由 E. coli 表达,带有 N-6*His 标签。SUMO1 蛋白, Human (His) 全长 101 个氨基酸,分子量为 17-19 kDa。

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规格 价格 是否有货 数量
10 μg ¥350 In-stock
50 μg ¥980 In-stock
100 μg   询价  

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描述

SUMO1 Protein is a member of the SUMO (small ubiquitin-like modifier) protein family. SUMO1 binds to target proteins as part of a post-translational modification system. It is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 also regulates the function of several proteins via non-covalent interactions. SUMO1 Protein, Human (His) is the recombinant human-derived SUMO1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SUMO1 Protein, Human (His) is 101 a.a., with molecular weight of 17-19 kDa.

研究背景

小泛素相关修饰物 1 (SUMO1) 是一种泛素样蛋白,是 SUMO 蛋白家族的成员。SUMO1 作为翻译后修饰系统的一部分与目标蛋白结合。它参与多种细胞过程,如核运输、转录调节、细胞凋亡和蛋白质稳定性。直到羧基末端的最后四个氨基酸被切除后,它才具有活性。SUMO1 还通过非共价相互作用调节几种蛋白质的功能,包括被鉴定为 SUMO 结合或相互作用基序 (SBM/SIM) 的靶蛋白中的疏水性补丁。SUMO1 通过诱导结构致密化阻止 α-突触核蛋白原纤化。SUMO1 作为修饰蛋白的蛋白酶体降解信号,并调节参与上颚发育的基因网络。它对于梗塞后心脏修复也至关重要,SUMO1 基因的缺失会加剧心肌梗塞 (MI) 后的心肌损伤[1][2][3][4]

种属

Human

表达系统

E. coli

标签

N-6*His

蛋白编号

AAH66306 (M1-V101)

基因 ID
蛋白结构
N-term
6*His
SUMO1 (M1-V101)
Accession # AAH66306
C-term
同用名
Small Ubiquitin-Related Modifier 1; SUMO-1; GAP-Modifying Protein 1; GMP1; SMT3 Homolog 3; Sentrin; Ubiquitin-Homology Domain Protein PIC1; Ubiquitin-Like Protein SMT3C; Smt3C; Ubiquitin-Like Protein UBL1; SUMO1; SMT3C; SMT3H3; UBL1
氨基酸序列

MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNNTPKELGMEEEDVIEVYQEQTGGHSTV

分子量

17-19 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, pH 8.5 .

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

SUMO1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
SUMO1 Protein, Human (His)
目录号:
HY-P70997
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