T-PA 蛋白, Mouse (HEK293, Fc)

The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond. This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration. T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction. T-PA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with N-hFc labeled tag. The total length of T-PA Protein, Mouse (HEK293, Fc) is 251 a.a., with molecular weight of 55-60 kDa.

T-PA 蛋白通过单个 Arg-Val 键的水解将无活性的酶原纤溶酶原转化为活性纤溶酶来发挥作用。这种转化对于调节纤溶酶介导的蛋白水解至关重要，蛋白水解参与组织重塑、降解、细胞迁移以及各种生理和病理过程。此外，在卵母细胞激活过程中，T-PA 在透明带反应内的皮质颗粒反应中发挥作用，有助于预防多精受精。

Mouse

HEK293

N-hFc

P11214 (I309-Q559)

18791  [NCBI]

IKGGLYTDITSHPWQAAIFVKNKRSPGERFLCGGVLISSCWVLSAAHCFLERFPPNHLKVVLGRTYRVVPGEEEQTFEIEKYIVHEEFDDDTYDNDIALLQLRSQSKQCAQESSSVGTACLPDPNLQLPDWTECELSGYGKHEASSPFFSDRLKEAHVRLYPSSRCTSQHLFNKTVTNNMLCAGDTRSGGNQDLHDACQGDSGGPLVCMINKQMTLTGIISWGLGCGQKDVPGVYTKVTNYLDWIHDNMKQ

55-60 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS, pH 7.4. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.