TARC/CCL17 蛋白, Mouse (His)

The TARC/CCL17 protein selectively attracts T lymphocytes, especially Th2 cells, emphasizing its critical role in inflammation and immunity. TARC/CCL17 binds to CCR4 on the surface of T cells, orchestrates immune responses, and contributes to GM-CSF/CSF2-driven pain and inflammation. TARC/CCL17 Protein, Mouse (His) is the recombinant mouse-derived TARC/CCL17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of TARC/CCL17 Protein, Mouse (His) is 70 a.a., with molecular weight of ~10 kDa.

TARC/CCL17 蛋白作为趋化因子发挥作用，对 T 淋巴细胞具有选择性趋化活性，特别是有利于 Th2 细胞而不是单核细胞或粒细胞。这种特异性强调了其在各种炎症和免疫过程中的关键作用。TARC/CCL17 通过与 T 细胞表面的 CCR4 结合发挥作用，有助于协调免疫反应。除了其免疫功能外，它还在 GM-CSF/CSF2 驱动的疼痛和炎症中发挥作用。值得注意的是，在大脑中，TARC/CCL17对于在稳态条件下维持海马小胶质细胞特征性的高度分支形态至关重要，并且可能在急性脂多糖（LPS）诱导的神经炎症期间调整小胶质细胞形态和突触可塑性方面发挥重要作用。此外，TARC/CCL17 主要通过诱导成纤维细胞迁移到伤口中来参与伤口愈合。这种多方面的功能凸显了 TARC/CCL17 在免疫反应和组织修复过程中的不同作用。

Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED₅₀ of this effect is 3.462 ng/ml, corresponding to a specific activity is 2.89×10⁵ units/mg.

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  Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED₅₀ of this effect is 3.462 ng/ml, corresponding to a specific activity is 2.89×10⁵ units/mg.

Mouse

E. coli

N-6*His

Q9WUZ6 (A24-P93)

20295  [NCBI]

ARATNVGRECCLDYFKGAIPIRKLVSWYKTSVECSRDAIVFLTVQGKLICADPKDKHVKKAIRLVKNPRP

Approximately 10 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.