TDGF1 蛋白, Human (HEK293, Fc)

The TDGF1 protein is a GPI-anchored cell membrane protein involved in Nodal signaling. TDGF1 Protein, Human (HEK293, Fc) is the recombinant human-derived TDGF1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TDGF1 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of ~51.0 kDa.

TDGF1 蛋白是一种 GPI 锚定的细胞膜蛋白，是 Nodal 信号传导的关键参与者。作为顺式细胞相关 CRIPTO 中的 Nodal 辅助受体，当 TMEM8A 脱落时，可通过使可溶性 CRIPTO 充当邻近细胞上的 Nodal 辅助受体来动态调节 Nodal 信号传导。这种脱落机制有助于节点信号通路的复杂调节。此外，TDGF1 参与外胚层细胞的决定，外胚层细胞随后形成中胚层，强调了其在早期发育过程中的重要性。值得注意的是，TDGF1 与 1 型激活素受体 ACVR1B 相互作用，进一步强调了其在介导关键细胞信号传导事件中的作用。

Human

HEK293

C-hFc

P13385 (L31-S169)

6997  [NCBI]

LGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPS

Approximately 51.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.