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TEAD3 蛋白, Human (His-SUMO)

目录号: HY-P71626
COA 产品使用指南

TEAD3 蛋白是一种转录因子,在 Hippo 信号通路中发挥关键作用,对于器官大小控制和肿瘤抑制至关重要。它通过涉及 MST1/MST2、SAV1、LATS1/2 和 MOB1 的激酶级联协调增殖抑制和凋亡促进。TEAD3 蛋白, Human (His-SUMO) 是重组的 TEAD3 蛋白,由 E. coli 表达,带有 N-SUMO, N-6*His 标签。TEAD3 蛋白, Human (His-SUMO) 全长 324 个氨基酸,分子量约为 ~52.3 kDa。

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描述

TEAD3 protein is a transcription factor that plays a key role in the Hippo signaling pathway and is essential for organ size control and tumor suppression. It coordinates proliferation inhibition and apoptosis promotion through a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1. TEAD3 Protein, Human (His-SUMO) is the recombinant human-derived TEAD3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of TEAD3 Protein, Human (His-SUMO) is 324 a.a., with molecular weight of ~52.3 kDa.

研究背景

TEAD3 是一种转录因子,在 Hippo 信号通路中发挥着关键作用,Hippo 信号通路是一个通过协调增殖抑制和促进细胞凋亡来控制器官大小和抑制肿瘤至关重要的调节网络。该途径的核心涉及激酶级联,其中 MST1/MST2 与其调节蛋白 SAV1 复合,磷酸化并激活与其调节伙伴 MOB1 复合的 LATS1/2。MOB1 随后磷酸化并灭活 YAP1 癌蛋白和 WWTR1/TAZ。TEAD3 通过介导 YAP1 和 WWTR1/TAZ 的基因表达发挥作用,从而调节细胞增殖、迁移和上皮间质转化 (EMT) 诱导。此外,TEAD3 还参与与人绒毛膜生长激素-B 基因增强子的多个功能元件的结合。它与 YAP1 和 WWTR1/TAZ 的相互作用强调了它在该信号通路的调节动态中的核心作用。

种属

Human

表达系统

E. coli

标签

N-SUMO;N-6*His

蛋白编号

Q99594 (112M-435D)

基因 ID
蛋白结构
N-term
6*His-SUMO
TEAD3 (112M-435D)
Accession # Q99594
C-term
同用名
DTEF 1; DTEF-1; DTEF1; ETFR 1; ETFR1; TEA domain family member 3; TEA domain family member 5; TEAD 3; TEAD-3; Tead3; TEAD5; TEF 5; TEF5; Transcriptional enhancer factor 5
氨基酸序列

MNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD

分子量

Approximately 52.3 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

TEAD3 Protein, Human (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TEAD3 Protein, Human (His-SUMO)
目录号:
HY-P71626
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