TEM8/ANTXR1 蛋白, Human (HEK293, His)

The TEM8/ANTXR1 protein is multifunctional in cell attachment and migration, interacting with extracellular matrix proteins and the actin cytoskeleton. This binding mediates cell adhesion to type 1 collagen and gelatin, promoting actin cytoskeletal reorganization and cell spreading, which is critical for cell structure and movement. TEM8/ANTXR1 Protein, Human (HEK293, His) is the recombinant human-derived TEM8/ANTXR1 protein, expressed by HEK293, with C-6*His labeled tag.

TEM8/ANTXR1 是一种多面蛋白，积极参与细胞附着和迁移。它与细胞外基质蛋白和肌动蛋白细胞骨架结合，介导细胞与 1 型胶原蛋白和明胶的粘附。这种相互作用促进了肌动蛋白细胞骨架的重组并促进细胞扩散，强调了其在细胞结构和运动中的关键作用。此外，TEM8/ANTXR1 有助于培养的脐静脉内皮细胞的血管生成反应，强调其参与血管发育。值得注意的是，在微生物感染情况下，TEM8/ANTXR1 作为炭疽杆菌保护性抗原 (PA) 的受体，突出了其在细胞过程和宿主-病原体相互作用中的双重作用。

Human

HEK293

C-6*His

Q9H6X2-4 (E33-K321)

84168

EDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSLHK

35-45 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.