TGFBR2/TGF-beta RII 蛋白, Mouse (HEK293, His)

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His), His consists of N-terminal ectodomain and C-terminal protein kinase domain with his tag. TGF-beta receptor type-2 is the ligand-binding receptor for all members of the TGF-β family.

转化生长因子-β (TGF-β) 是一种多效性细胞因子，能够根据细胞环境充当肿瘤抑制因子或肿瘤促进因子。2 型 TGF-β 受体 (TGFBR2) 是 TGF-β 家族所有成员的配体结合受体，在包括成纤维细胞在内的几乎所有细胞类型中表达。通过成纤维细胞 TGF-β 途径调节肿瘤间质相互作用可能取决于成纤维细胞表型，这强调了表征肿瘤微环境亚型的重要性^[1]。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

N-6*His

Q62312-2 (I24-D159)

21813  [NCBI]

IPPHVPKSVNSDVMASDNGGAVKLPQLCKFCDVRLSTCDNQKSCMSNCSITAICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHGFTLEDAASPKCVMKEKKRAGETFFMCACNMEECNDYIIFSEEYTTSSPDHHHHHH

25-38 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Busch S, et al. TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer. Oncogene. 2015 Jan 2;34(1):27-38.  [Content Brief]