TGFBR2/TGF-beta RII 蛋白, Rhesus Macaque (HEK293, Fc)

TGFBR2/TGF-beta RII Protein collaborates with TGFBR1 to form a dedicated receptor for TGFB1, TGFB2, and TGFB3. It serves as a signal transducer, orchestrating diverse physiological and pathological processes, including cell cycle regulation, mesenchymal cell dynamics, wound healing, matrix production, immunosuppression, and carcinogenesis. Upon cytokine binding, the receptor complex activates TGFBR1 through TGFBR2 phosphorylation, initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 participates in non-canonical, SMAD-independent pathways. TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rhesus Macaque (HEK293, Fc) is 136 a.a., with molecular weight of ~50-70 KDa.

TGFBR2 (TGF-β RII) 与 TGF-β I 型丝氨酸/苏氨酸激酶受体 TGFBR1 协作，形成 TGF-β 细胞因子的专用受体，包括 TGFB1、TGFB2 和 TGFB3。TGFBR2 作为信号转导器，介导 TGFB1、TGFB2 和 TGFB3 信号从细胞表面到细胞质的传递，从而协调多种生理和病理过程。这些包括上皮细胞和造血细胞的细胞周期停滞、间充质细胞增殖和分化的调节、伤口愈合、细胞外基质的产生、免疫抑制和致癌作用。该受体复合物包含与细胞因子二聚体对称结合的 2 个 TGFBR1 和 2 个 TGFBR2 分子，导致 TGFBR1 被组成型活性 TGFBR2 磷酸化和激活。激活的 TGFBR1 随后磷酸化 SMAD2，导致其与受体解离并与 SMAD4 相互作用。由此产生的 SMAD2-SMAD4 复合物易位到细胞核，在细胞核中调节 TGF-β 调节基因的转录，构成典型的 SMAD 依赖性 TGF-β 信号级联。此外，TGFBR2 参与非经典、不依赖 SMAD 的 TGF-β 信号传导途径，并表现出转化生长因子 β 激活受体活性^[1][2]。

Immobilized Rhesus TGFB1-His at 10 μg/mL (100 μL/well) can bind Rhesus TGFBR2. The ED₅₀ for this effect is 25.22 ng/mL.

Rhesus Macaque

HEK293

C-hFc

NP_001248080.1 (I24-D159)

703088  [NCBI]

IPPHVQKSVNNDMMVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCLSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPD

Approximately 50-70 kDa.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.