Thymidine kinase 1/TK1 蛋白, Human (HEK293, His)

The thymidine kinase 1/TK1 protein acts as a cell surface receptor in the FCGRT protein. This receptor promotes the transfer of passive humoral immunity from mother to newborn by selectively binding to monomeric immunoglobulin gamma in milk. Thymidine kinase 1/TK1 Protein, Human (HEK293, His) is the recombinant human-derived Thymidine kinase 1/TK1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thymidine kinase 1/TK1 Protein, Human (HEK293, His) is 234 a.a., with molecular weight of ~29.58 kDa.

FCGRT-B2M 异二聚体蛋白作为细胞表面受体，促进被动体液免疫从母亲转移到新生儿。它选择性地结合单体免疫球蛋白 γ 的 Fc 区，尤其是在牛奶中，从而能够在肠上皮的顶端表面摄取 IgG。然后形成的 FcRn-IgG 复合物在上皮细胞中转胞吞，将 IgG 释放到血液或组织液中。除了生命早期，这种受体通过回收 IgG 并延长其在循环中的半衰期，在维持有效的体液免疫方面发挥着至关重要的作用。该机制涉及单体 IgG 与酸性核内体中的 FcRn 结合，导致 IgG 循环至细胞表面并随后释放到循环中。值得注意的是，FCGRT-B2M 异二聚体还调节白蛋白（最丰富的循环蛋白）的稳态，突显其在免疫和代谢过程中的多方面作用。FcRn复合物由两个亚基组成：p51和p14，后者相当于β-2-微球蛋白，形成MHC I类样异二聚体。此外，它与白蛋白相互作用，有助于白蛋白稳态的调节。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P04183 (M1-N234)

7083  [NCBI]

MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

Approximately 29.58 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 2 mM EDTA, 10% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.