2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  4. Angiopoietins Endothelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. TIE-2/CD202b TIE Receptors
  6. TIE-2
  7. TIE-2 蛋白, Human (HEK293, His-Fc)

TIE-2 蛋白, Human (HEK293, His-Fc)

目录号: HY-P73434
产品使用指南

TIE2 蛋白是 ANGPT1、ANGPT2 和 ANGPT4 的细胞表面受体，属于蛋白酪氨酸激酶 Tie2 家族成员。TIE2 蛋白是一种促血管生成素因子，调节血管生成、内皮细胞存活、增殖、迁移、粘附、细胞扩散，以及肌动蛋白细胞骨架的重组，并且具有抗炎作用。TIE2 蛋白 由 1124 个氨基酸组成 (M1-A1124)，存在两个免疫球蛋白样结构域 3 个 N 端纤维连接蛋白 III 型结构域 (447-541 a.a, 545-636 a.a, 641-735 a.a) 和三个表皮生长因子 (EGF) 样结构域 (210-252 a.a, 254-299 a.a, 301-341 a.a)。TIE-2 蛋白, Human (HEK293, His-Fc) 是重组的 TIE-2 蛋白，由 HEK293 表达，带有 C-hFc, C-His 标签。TIE-2 蛋白, Human (HEK293, His-Fc) 全长 723 个氨基酸，分子量约为 ~130.7 kDa。

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描述

TIE2 Protein is a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4, belonging to the protein tyrosine kinase Tie2 family. TIE2 Protein is an angiogenic factor that regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion, cell spreading, and actin cytoskeleton reorganization, and has anti-inflammatory effects. TIE2 Protein consists of 1124 amino acids (M1-A1124), with two immunoglobulin-like domains, three N-terminal fibronectin type III domains (447-541 a.a, 545-636 a.a, 641-735 a.a), and three epidermal growth factor (EGF)-like domains (210-252 a.a, 254-299 a.a, 301-341 a.a). TIE-2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived TIE-2 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TIE-2 Protein, Human (HEK293, His-Fc) is 723 a.a., with molecular weight of ~130.7 kDa.
研究背景

TIE2 Protein 与血管生成素-1 结合，介导了在胚胎血管发育中起作用的信号通路。TIE2 Protein 通过调节促炎血浆蛋白和白细胞从血管中的活动而具有抗炎作用。TIE2 Protein 调节血管生成、内皮细胞存活、增殖、迁移、粘附、细胞扩散，以及肌动蛋白细胞骨架的重组。TIE2 Protein 的表达能促进肿瘤的血管生成，加速肿瘤的生长转移[1][2]。
种属

Human
表达系统

HEK293
标签

C-hFc;C-His
蛋白编号

AAA61139.1 (A23-K745)
基因 ID
蛋白结构
N-term
TIE-2 (A23-K745)
Accession # AAA61139.1
hFc-His
C-term
同用名
Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; Tie2; VMCM
分子量

Approximately 130.7 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TIE-2 Protein, Human (HEK293, His-Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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