1. 重组蛋白
  2. Immune Checkpoint Proteins Biotinylated Proteins
  3. Inhibitory Checkpoint Molecules
  4. TIGIT Protein
  5. TIGIT 蛋白, Human (HEK293, His-Avi)

TIGIT 蛋白, Human (HEK293, His-Avi)

目录号: HY-P72418
产品使用指南

TIGIT 蛋白在免疫调节中发挥着关键作用,与脊髓灰质炎病毒受体 (PVR) 具有高亲和力结合。这种相互作用通过增加 IL10 分泌和减少 IL12B 分泌来诱导免疫抑制环境。TIGIT 抑制 T 细胞活化,促进成熟的免疫调节树突状细胞生成,并形成具有高亲和力 PVR 结合的顺式同二聚体。它还表现出与 NECTIN2 和 NECTIN3 的较低亲和力结合,展示了多种分子相互作用。TIGIT 的多方面功能强调了其在免疫调节中的关键作用及其作为调节免疫反应的治疗靶点的潜力。TIGIT Protein, Human (HEK293, His-Avi) 是重组的 TIGIT 蛋白,由 HEK293 表达,带有 C-Avi, C-6*His 标签。TIGIT Protein, Human (HEK293, His-Avi) 全长 120 个氨基酸,分子量为 17-23 kDa。

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描述

TIGIT Protein plays a pivotal role in immune regulation, binding with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT suppresses T-cell activation, promotes mature immunoregulatory dendritic cell generation, and forms a homodimer in cis with high-affinity PVR binding. It also exhibits lower-affinity binding to NECTIN2 and NECTIN3, showcasing diverse molecular interactions. TIGIT's multifaceted functions underscore its crucial role in immune regulation and its potential as a therapeutic target for modulating immune responses. TIGIT Protein, Human (HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293, with C-Avi, C-6*His labeled tag. The total length of TIGIT Protein, Human (HEK293, His-Avi) is 120 a.a., with molecular weight of 17-23 kDa.

研究背景

TIGIT 蛋白在免疫调节中发挥着关键作用,与脊髓灰质炎病毒受体 (PVR) 表现出高亲和力结合。这种相互作用导致 IL10 分泌增加和 IL12B 分泌减少,从而形成免疫抑制环境。TIGIT通过抑制T细胞活化和促进成熟免疫调节树突状细胞的生成进一步发挥其免疫调节作用。在结构上,TIGIT 形成顺式同二聚体,以高亲和力与 PVR 结合,从而产生包含两个 TIGIT 和两个 PVR 分子的异四聚体组装体。此外,TIGIT 与 NECTIN2 和 NECTIN3 的结合亲和力较低,强调了其多种分子相互作用的能力。TIGIT 的多方面功能和结合亲和力凸显了其在免疫调节中的关键作用及其作为调节免疫反应的治疗靶点的潜力。

种属

Human

表达系统

HEK293

标签

C-Avi;C-6*His

蛋白编号

Q495A1-1 (M22-P141)

基因 ID
蛋白结构
N-term
TIGIT (M22-P141)
Accession # Q495A1-1
6*His-Avi
C-term
同用名
T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3
氨基酸序列

MMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIP

分子量

17-23 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TIGIT Protein, Human (HEK293, His-Avi)
目录号:
HY-P72418
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