1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Inhibitory Checkpoint Molecules
  4. TIGIT Protein
  5. TIGIT 蛋白, Mouse (110a.a, HEK293, His)

TIGIT 蛋白, Mouse (110a.a, HEK293, His)

目录号: HY-P72449
COA 产品使用指南

TIGIT 蛋白具有信号传导受体结合活性,在 T 细胞激活抑制的上游发挥作用。它活跃于细胞表面,与人类 TIGIT 具有同源性。TIGIT 与调节 T 细胞反应相关,表现出偏向表达,特别是在大肠、小肠和其他组织中。这凸显了其在这些背景下免疫调节的潜力。TIGIT Protein, Mouse (110a.a, HEK293, His) 是重组的 TIGIT 蛋白,由 HEK293 表达,带有 C-6*His 标签。TIGIT Protein, Mouse (110a.a, HEK293, His) 全长 110 个氨基酸,分子量为 15-22 kDa。

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规格 价格 是否有货 数量
10 μg ¥1520 In-stock
50 μg ¥4000 In-stock
100 μg   询价  

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描述

TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (110a.a, HEK293, His) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Mouse (110a.a, HEK293, His) is 110 a.a., with molecular weight of 15-22 kDa.

研究背景

TIGIT 蛋白以其信号受体结合活性为特征,在 T 细胞激活的负调节上游发挥作用。该蛋白预计在细胞表面具有活性,与人 TIGIT(具有 Ig 和 ITIM 结构域的 T 细胞免疫受体)同源,与 T 细胞反应的调节相关。TIGIT 的表达存在偏差,在大肠、小肠和其他几种组织中观察到显着水平,强调了其在这些环境中免疫调节中的潜在作用。

种属

Mouse

表达系统

HEK293

标签

C-6*His

蛋白编号

NP_001139797 (G26-F135)

基因 ID

100043314  [NCBI]

蛋白结构
N-term
TIGIT (G26-F135)
Accession # NP_001139797
6*His
C-term
同用名
T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3
氨基酸序列

GTIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSVAQF

分子量

15-22 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

TIGIT Protein, Mouse (110a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TIGIT Protein, Mouse (110a.a, HEK293, His)
目录号:
HY-P72449
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