Tissue Factor 蛋白, Cynomolgus (HEK293, His)

F3 Protein, a cell surface receptor, plays a significant role in regulating blood coagulation and promoting cell adhesion. Dysregulation of F3 Protein has been associated with various disorders, including thrombosis and cancer. Targeting F3 Protein may offer potential therapeutic interventions in these conditions by inhibiting blood clot formation and preventing tumor cell adhesion and metastasis. Tissue Factor Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Cynomolgus (HEK293, His) is 220 a.a., with molecular weight of approximately 34-50 kDa.

F3 蛋白，也称为组织因子 (TF)，通过与循环因子 VII 或 VIIa 形成复合物而充当血液凝固的引发剂。这种复合物 [TF:VIIa] 通过特定的有限蛋白水解触发因子 IX 或 X 的激活。在正常止血过程中，TF 在启动细胞表面凝血蛋白酶级联的组装和传播方面发挥着至关重要的作用。此外，F3 蛋白与 HSPE 相互作用，而这种相互作用会受到肝素的阻碍。这种相互作用促进了活化因子 X 的产生，并在活化因子 VII 存在的情况下激活凝血。

Measured by its ability to activate Coagulation Factor VII in cleaving a fluorogenic peptide substrate Boc-VPR-AMC. The AC50 is 6.991 μg/mL, as measured under the described conditions, corresponding to a specific activity is 143.041 units/mg.

Cynomolgus

HEK293

C-His

A0A2K5VX02-1 (S33-E252)

102131431

SGTTNTVAAYNLTWKSTNFKTILEWEPKPINQVYTVQISTKSGDWKSKCFYTADTECDLTDEIVKDVKQTYLARVFSYPAGHVESTGSTEEPPYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVQDEWTLVRRNDTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRRTANRKSTDSPVECMGHEKGESRE

approximately 34-50 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.