Tissue Factor 蛋白, Rat (HEK293, His)

Tissue Factor Protein plays a critical role in blood coagulation. It binds to coagulation factors, activating clotting cascades. Tissue Factor Protein interacts with cells, promoting thrombosis and inflammation. Understanding its functions can aid in developing treatments for blood disorders and cardiovascular diseases. Tissue Factor Protein, Rat (HEK293, His) is the recombinant rat-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Rat (HEK293, His) is 252 a.a., with molecular weight of 47-52 kDa.

组织因子 (TF) 是凝血的关键引发剂，与循环因子 VII 或 VIIa 形成复合物。这种 [TF:VIIa] 复合物对于通过特定的有限蛋白水解激活因子 IX 或 X 至关重要。在正常止血中，TF 通过启动细胞表面组装和凝血蛋白酶级联的传播发挥着至关重要的作用。此外，TF 与 HSPE 相互作用；然而，这种相互作用会被肝素抑制。值得注意的是，这种相互作用促进了活化因子 X 的生成，并在活化因子 VII 存在的情况下激活凝血，强调了 TF 在复杂的血液凝固过程中的多方面作用。

Rat

HEK293

C-His

Q66HI4 (M1-E252)

25584  [NCBI]

MAIPMRPRLLAALAPTFLGFLLLQVAAGAGTPPGKAFNLTWISTDFKTILEWQPKPTNYTYTVQISDRSRNWKYKCTGTTDTECDLTDEIVKDVNWTYEARVLSVPWRNSTHGKETLFGTHGEEPPFTNARKFLPYRDTKIGQPVIQKYEQDGTKLKVTVKDSFTLVRKNGTFLTLRQVFGNDLGYILTYRKDSSTGRKTNTTHTNEFLIDVEKGVSYCFFVQAVIFSRKTNHKSPESITKCTEQWKSVLGE

47-52 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.