1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. T Cell CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors
  4. CD282/TLR2 Toll-like Receptor
  5. Toll Like Receptor 2
  6. TLR2 蛋白, Mouse (sf9, His)

TLR2 蛋白, Mouse (sf9, His)

目录号: HY-P73590
COA 产品使用指南

TLR2 蛋白与 LY96 协同启动针对细菌脂蛋白和细胞壁成分的免疫反应。它与TLR1或TLR6协同激活NF-κ-B,诱导细胞因子分泌,形成TLR2:TLR6:CD14:CD36等激活簇。TLR2 蛋白, Mouse (sf9, His) 是重组的 TLR2 蛋白,由 Sf9 insect cells 表达,带有 C-His 标签。TLR2 蛋白, Mouse (sf9, His) 全长 587 个氨基酸,分子量约为 ~65 kDa。

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规格 价格 是否有货 数量
50 μg ¥4200 In-stock
100 μg   询价  

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描述

The TLR2 protein cooperates with LY96 to initiate an immune response against bacterial lipoproteins and cell wall components. It cooperates with TLR1 or TLR6 to activate NF-kappa-B, induce cytokine secretion, and form activation clusters such as TLR2:TLR6:CD14:CD36. TLR2 Protein, Mouse (sf9, His) is the recombinant mouse-derived TLR2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TLR2 Protein, Mouse (sf9, His) is 587 a.a., with molecular weight of ~65 kDa.

研究背景

TLR2 蛋白与 LY96 合作启动针对细菌脂蛋白和微生物细胞壁成分的先天免疫反应。此外,它还与TLR1或TLR6配合对特定脂肽做出反应,通过MYD88和TRAF6作用激活NF-kappa-B,诱导细胞因子分泌,引发炎症。TLR2 响应不同的配体形成激活簇,如 TLR2:TLR6:CD14:CD36 和 TLR2:TLR1:CD14,导致细胞表面信号传导和随后通过脂筏依赖性途径靶向高尔基体。值得注意的是,TLR2 识别结核分枝杆菌抗原,包括 EsxA (ESAT-6),并作为各种结核分枝杆菌脂蛋白的主要受体,影响抗原呈递细胞功能。它与 TICAM2、LY96、TLR1、TLR6、MYD88、TICAM1、CNPY3、ATG16L1、未修饰的结核分枝杆菌蛋白 MPT83、PPP1R11 和 TIRAP 的相互作用有助于其在免疫反应中发挥多种作用。

种属

Mouse

表达系统

Sf9 insect cells

标签

C-His

蛋白编号

Q9QUN7 (M1-Q587)

基因 ID
蛋白结构
N-term
TLR2 (M1-Q587)
Accession # Q9QUN7
His
C-term
同用名
CD282; TIL4; TLR2; Toll-like receptor 2
分子量

Approximately 65 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, pH 7.4, 10% Glycerol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TLR2 Protein, Mouse (sf9, His)
目录号:
HY-P73590
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