2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Osteoprotegerin
  7. TNFRSF11B/OPG 蛋白, Human (HEK293, hFc-Flag)

TNFRSF11B/OPG 蛋白, Human (HEK293, hFc-Flag)

目录号: HY-P700432
产品使用指南

TNFRSF11B/OPG 作为 TNFSF11/RANKL 的诱饵受体，中和其破骨细胞作用并促进体外破骨细胞凋亡。它调节 TNFSF11/TNFRSF11B 比率，对于骨稳态至关重要。此外，TNFRSF11B 可以防止动脉钙化，充当 TNFSF10/TRAIL 的诱饵受体来抑制细胞凋亡。同二聚体结构使 TNFRSF11B 能够与 TNFSF10 和 TNFSF11 相互作用，调节骨代谢和细胞存活的重要途径。TNFRSF11B/OPG 蛋白, Human (HEK293, hFc-Flag) 是重组的 TNFRSF11B/OPG 蛋白，由 HEK293 表达，带有 C-hFc, C-Flag 标签。TNFRSF11B/OPG 蛋白, Human (HEK293, hFc-Flag) 全长 380 个氨基酸，分子量为 73.5 kDa。

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描述

TNFRSF11B/OPG functions as a decoy receptor for TNFSF11/RANKL, neutralizing its osteoclastogenic effects and promoting osteoclast apoptosis in vitro. Crucial for bone homeostasis, it modulates the TNFSF11/TNFRSF11B ratio. Additionally, TNFRSF11B may prevent arterial calcification, acting as a decoy receptor for TNFSF10/TRAIL to inhibit apoptosis. The homodimeric structure enables TNFRSF11B to interact with TNFSF10 and TNFSF11, regulating essential pathways in bone metabolism and cellular survival. TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived TNFRSF11B/OPG protein, expressed by HEK293, with C-hFc, C-Flag labeled tag. The total length of TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) is 380 a.a., with molecular weight of 73.5 kDa.
研究背景

TNFRSF11B/OPG 作为 TNFSF11/RANKL 的诱饵受体，有效中和其在破骨细胞生成中的功能。它抑制破骨细胞的激活，在体外促进破骨细胞凋亡，通过调节 TNFSF11 和 TNFRSF11B 之间的局部比例，突显其在骨稳态中的关键作用。此外，TNFRSF11B 可能在预防动脉钙化中发挥作用，并作为 TNFSF10/TRAIL 的诱饵受体，提供针对细胞凋亡的保护。TNFRSF11B 的同二聚体结构强调了其与 TNFSF10 和 TNFSF11 相互作用的能力，从而调节骨代谢和细胞存活的重要途径。
种属

Human
表达系统

HEK293
标签

C-hFc;C-Flag
蛋白编号

O00300 (E22-L401)
基因 ID
蛋白结构
N-term
TNFRSF11B (E22-L401)
Accession # O00300
hFc-Flag
C-term
同用名
Tumor Necrosis Factor Receptor Superfamily Member 11B; Osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG
氨基酸序列

ETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL

分子量

73.5 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TNFRSF11B/OPG Protein, Human (HEK293, hFc-Flag) 相关分类

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