TRAT1 蛋白, Human (His)

TRAT1 protein stabilizes the T-cell antigen receptor (TCR)/CD3 complex on T-cell surfaces. As a homodimer linked by disulfide bonds, TRAT1 interacts with CD3Z, enhancing the structural integrity and function of the TCR/CD3 complex. Phosphorylated TRAT1 also engages with PIK3R1, indicating its role in signaling pathways related to T-cell activation and response. TRAT1 Protein, Human (His) is the recombinant human-derived TRAT1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of TRAT1 Protein, Human (His) is 158 a.a., with molecular weight of ~30.0 kDa.

T 细胞受体相关跨膜接头 1 (TRAT1) 蛋白充当 T 细胞表面 T 细胞抗原受体 (TCR)/CD3 复合物的稳定剂。TRAT1 通过二硫键作为同二聚体存在，与 CD3Z 相互作用，有助于 TCR/CD3 复合物的结构完整性和正常功能。磷酸化后，TRAT1 进一步与 PIK3R1 相互作用，表明其参与与 T 细胞激活和反应相关的信号通路。

Human

E. coli

C-6*His

Q6PIZ9 (N29-N186)

50852  [NCBI]

NISHYVEKQRQDKMYSYSSDHTRVDEYYIEDTPIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQATNETQMCYASLDHSVKGKRRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPESQAVEENIHDDPIRLFGLIRAKREPIN

Approximately 30.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, 20% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.