TREM-1 蛋白, Human (180a.a, HEK293, His)

The TREM-1 protein is a cell surface receptor that critically regulates innate and adaptive immunity by enhancing inflammatory responses. TREM-1 plays a crucial role in acute and chronic inflammatory diseases, acting as a decoy receptor to balance its pro-inflammatory effects. TREM-1 Protein, Human (180a.a, HEK293, His) is the recombinant human-derived TREM-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREM-1 Protein, Human (180a.a, HEK293, His) is 180 a.a., with molecular weight of 26-40 kDa.

TREM-1 蛋白作为细胞表面受体，可能参与先天性和适应性免疫反应。磷酸化后，它与 PTPN6 和 PTPN11 相互作用，表明它在与这些磷酸酶相关的信号通路中的作用。这种相互作用凸显了 TREM-1 可能有助于调节免疫系统的调节机制。

Measured by its ability to block anti-TREM-1-induced TNF-alpha secretion by human myeloid leukemia mononuclear cells. At 1 µg/mL, Recombinant Human TREM-1 is able to block is 63% of Anti-Human TREM-1 (20 µg/mL, 200 µL/well) induced TNF-alpha released from 1 x 10⁵ cells.

Human

HEK293

C-6*His

Q9NP99 (A21-R200)

54210  [NCBI]

ATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIR

26-40 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2 or PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.