UBE2J2 蛋白, Human (GST)

The UBE2J2 protein plays a crucial role in cellular processes by catalyzing the covalent attachment of ubiquitin to other proteins. Its function is involved in the selective degradation of misfolded membrane proteins extending into the endoplasmic reticulum (ERAD), as suggested by the similarity of related processes. UBE2J2 Protein, Human (GST) is the recombinant human-derived UBE2J2 protein, expressed by E. coli , with N-GST labeled tag. The total length of UBE2J2 Protein, Human (GST) is 101 a.a., with molecular weight of 30 & 36 kDa, respectively.

UBE2J2（或泛素结合酶 E2 J2）是一种在泛素与其他蛋白质共价连接中发挥核心作用的蛋白质，这一过程对于调节蛋白质稳定性和降解至关重要。UBE2J2 被认为在内质网 (ERAD) 中选择性降解错误折叠膜蛋白，表明其参与细胞质量控制机制。此外，UBE2J2 与 GATOR2 复合体合作，催化 NPRL2 的“Lys-6”连接泛素化，表明其通过泛素修饰参与细胞过程的调节。参考文献强调了 UBE2J2 在 ERAD 和特定靶标泛素化中的双重作用，说明了其参与多种细胞途径的多功能性。

Human

E. coli

N-GST

Q8N2K1 (E124-R224)

118424  [NCBI]

EKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANR

30&36 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.