1. 重组蛋白
  2. Ubiquitin Related Proteins
  3. Ubiquitin Enzymes
  4. E2 Enzymes
  5. Ubiquitin Conjugating Enzyme E2 L6
  6. UBE2L6 蛋白, Human (His)

UBE2L6 蛋白, Human (His)

目录号: HY-P71020
产品使用指南

UBE2L6 蛋白通过催化泛素或 ISG15 与其他蛋白的共价连接,在细胞调节中发挥关键作用。值得注意的是,它在 E6/E6-AP 诱导的 p53/TP53 泛素化中发挥作用,这是调节细胞对应激和 DNA 损伤反应的核心过程。UBE2L6 蛋白, Human (His) 是重组的 UBE2L6 蛋白,由 E. coli 表达,带有 C-6*His 标签。UBE2L6 蛋白, Human (His) 全长 153 个氨基酸,分子量约为 ~17.0 kDa。

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100 μg   询价  

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描述

The UBE2L6 protein plays a key role in cell regulation by catalyzing the covalent attachment of ubiquitin or ISG15 to other proteins. Notably, it plays a role in E6/E6-AP-induced ubiquitination of p53/TP53, a core process in regulating cellular responses to stress and DNA damage. UBE2L6 Protein, Human (His) is the recombinant human-derived UBE2L6 protein, expressed by E. coli , with C-6*His labeled tag. The total length of UBE2L6 Protein, Human (His) is 153 a.a., with molecular weight of ~17.0 kDa.

研究背景

UBE2L6,也称为泛素结合酶 E2L6,是一种催化泛素或 ISG15 与其他蛋白质共价连接的蛋白质,这是调节蛋白质稳定性和功能的关键过程。具体来说,UBE2L6 在 E6/E6-AP 诱导的 p53/TP53 泛素化中发挥作用,p53/TP53 是一种参与细胞周期调节和细胞凋亡的肿瘤抑制蛋白。此外,UBE2L6 还参与促进 FLT3 的泛素化和随后的蛋白酶体降解,FLT3 是一种与细胞增殖和分化相关的受体酪氨酸激酶。通过这些泛素化事件,UBE2L6 有助于特定蛋白质的靶向降解,影响细胞途径和过程,特别是与细胞周期控制和信号级联相关的途径和过程。

种属

Human

表达系统

E. coli

标签

C-6*His

蛋白编号

O14933 (M1-S153)

基因 ID
蛋白结构
N-term
UBE2L6 (M1-S153)
Accession # O14933
6*His
C-term
同用名
Ubiquitin/ISG15-Conjugating Enzyme E2 L6; Retinoic Acid-Induced Gene B Protein; RIG-B; UbcH8; Ubiquitin Carrier Protein L6; Ubiquitin-Protein Ligase L6; UBE2L6; UBCH8
氨基酸序列

MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

分子量

Approximately 17.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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