UDP-glucose 4-epimerase/GALE 蛋白, Human (His)

GALE proteins catalyze the reversible epimerization of UDP-glucose to UDP-galactose, and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. UDP-glucose 4-epimerase/GALE Protein, Human (His) is the recombinant human-derived UDP-glucose 4-epimerase/GALE protein, expressed by E. coli , with N-6*His labeled tag. The total length of UDP-glucose 4-epimerase/GALE Protein, Human (His) is 348 a.a., with molecular weight of ~38.23 kDa.

UDP-葡萄糖4-差向异构酶（GALE）蛋白协调两个不同但相似的反应：UDP-葡萄糖到UDP-半乳糖的可逆差向异构化和UDP-N-乙酰葡糖胺到UDP-N-乙酰半乳糖胺的可逆差向异构化。UDP-葡萄糖向 UDP-半乳糖的转化在半乳糖分解代谢的 Leloir 途径中至关重要，它将半乳糖引导成糖酵解中间体葡萄糖 6-磷酸。GALE 在膳食半乳糖的分解中发挥着关键作用，并且在外部来源有限时促进 UDP-Gal 和 UDP-GalNAc 的内源生物合成。这些 UDP-糖相互转化是糖蛋白和糖脂合成所涉及的复杂过程不可或缺的一部分，强调了 GALE 在细胞聚糖生物合成中的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

Q14376 (M1-A348)

2582  [NCBI]

MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

Approximately 38.23 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 2 mM DTT, 1 mM EDTA, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.