uPAR 蛋白, Mouse (HEK293, His-Fc)

uPAR (urokinase plasminogen activator receptor) possesses enzyme, protein, and receptor binding activities. It regulates apoptotic signaling, epidermal growth factor signaling, and cytochrome c release. uPAR is widely expressed in structures like decidua and spleen. Its human ortholog, PLAUR, is linked to rheumatoid arthritis. Investigating uPAR can reveal its role in cellular processes and shed light on diseases like rheumatoid arthritis. uPAR Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of uPAR Protein, Mouse (HEK293, His-Fc) is 274 a.a., with molecular weight of 80-90 kDa.

uPAR（尿激酶纤溶酶原激活剂受体）是一种多面蛋白质，预计具有酶结合活性、蛋白质结构域特异性结合活性和信号受体结合活性。预计它在多种过程中发挥作用，包括细胞凋亡信号通路的负调节、表皮生长因子受体信号通路的正调节以及线粒体释放细胞色素c的正调节。作为质膜的一个组成部分，uPAR 在蜕膜、早期概念和脾脏等多种结构中表现出广泛的表达。该基因的人类直系同源物 PLAUR（纤溶酶原激活剂、尿激酶受体）对类风湿性关节炎等疾病具有影响，凸显了 uPAR 在生理和病理环境中的潜在意义。对 uPAR 的研究可能会揭示其在细胞过程中的复杂参与，并有助于我们了解类风湿性关节炎等疾病。

Immobilized Recombinant rmuPAR/Fc at 5 μg/mL (100 μL/well) can bind Biotinylated Recombinant rhuPA Protein. The ED₅₀ for this effect is <50.73 ng/mL.

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  Immobilized Recombinant rmuPAR/Fc at 5 μg/mL (100 μL/well) can bind Biotinylated Recombinant rhuPA Protein. The ED₅₀ for this effect is 50.73 ng/mL.

Mouse

HEK293

C-hFc;C-His

NP_035243.1 (L24-T297)

18793  [NCBI]

LQCMQCESNQSCLVEECALGQDLCRTTVLREWQDDRELEVVTRGCAHSEKTNRTMSYRMGSMIISLTETVCATNLCNRPRPGARGRAFPQGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSLKDEDYTRGCGSLPGCPGTAGFHSNQTFHFLKCCNYTHCNGGPVLDLQSFPPNGFQCYSCEGNNTLGCSSEEASLINCRGPMNQCLVATGLDVLGNRSYTVRGCATASWCQGSHVADSFPTHLNVSVSCCHGSGCNSPT

80-90 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.