USH1C 蛋白, Human (His-SUMO)

USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of USH1C Protein, Human (His-SUMO) is 533 a.a., with molecular weight of ~76.3 kDa.

USH1C 是一种锚定和支架蛋白，在耳蜗毛细胞内的力转导过程中发挥着至关重要的作用，与 USH1G、CDH23 和 MYO7A 形成复杂的网络。它对于耳蜗毛细胞束的正常发育和维持至关重要。作为微绒毛间粘附复合物 (IMAC) 的组成部分，USH1C 有助于刷状缘分化，从而控制微绒毛的组织和长度。它的调节意义在复合物的组装中很明显，它将 CDHR2、CDHR5 和 MYO7B 招募到微绒毛的尖端。USH1C参与多种复合体，包括IMAC以及由USH1C、USH1G和MYO7A组成的复合体。其相互作用延伸至 F-肌动蛋白、USH2A、SLC4A7、USHBP1、CDH23、USH1G、MYO7B、CDHR2、CDHR5 和 ANKS4B，强调其在细胞过程和蛋白质关联中的多方面作用。

Human

E. coli

N-His;N-SUMO

Q9Y6N9-4(M1-F533)

10083  [NCBI]

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF

Approximately 76.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.