USH1C 蛋白, Human (His)

USH1C, an anchoring and scaffolding protein, is crucial for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23, and MYO7A, contributing to the development and maintenance of hair cell bundles. As part of the intermicrovillar adhesion complex (IMAC), USH1C regulates brush border differentiation, influencing microvilli organization and length. It recruits CDHR2, CDHR5, and MYO7B to microvilli tips, participating in complexes like IMAC, USH1C/USH1G/MYO7A, and interacting with various proteins, highlighting its multifaceted role. USH1C Protein, Human (His) is the recombinant human-derived USH1C protein, expressed by E. coli, with N-6*His labeled tag. The total length of USH1C Protein, Human (His) is 552 a.a., with molecular weight of ~70 kDa.

USH1C 是一种锚定和支架蛋白，在耳蜗毛细胞内的力转导过程中发挥着至关重要的作用，与 USH1G、CDH23 和 MYO7A 形成复杂的网络。它对于耳蜗毛细胞束的正常发育和维持至关重要。作为微绒毛间粘附复合物 (IMAC) 的组成部分，USH1C 有助于刷状缘分化，从而控制微绒毛的组织和长度。它的调节意义在复合物的组装中很明显，它将 CDHR2、CDHR5 和 MYO7B 招募到微绒毛的尖端。USH1C参与多种复合体，包括IMAC以及由USH1C、USH1G和MYO7A组成的复合体。其相互作用延伸至 F-肌动蛋白、USH2A、SLC4A7、USHBP1、CDH23、USH1G、MYO7B、CDHR2、CDHR5 和 ANKS4B，强调其在细胞过程和蛋白质关联中的多方面作用。

Data is not available.

Human

E. coli

N-6*His

Q9Y6N9 (M1-F552)

10083  [NCBI]

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF

Approximately 70 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, pH 7.4, 20% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.