USP4 蛋白, Human (Active, sf9, His, Flag)

USP4 Protein, Human (Active, sf9, His, Flag) is the recombinant human-derived USP4, expressed by sf9 insect cells , with His, Flag labeled tag. ,

USP4 是一种去泛素化酶，能够从靶蛋白上移除结合的泛素分子。其功能包括：对 PDPK1 进行去泛素化；对 TRIM21 进行去泛素化；对受体 ADORA2A 进行去泛素化，从而增加细胞表面功能性受体的数量；对 HAS2 进行去泛素化；在 EGF 信号传导过程中对 RHEB 进行去泛素化，促进 mTORC1 信号通路；可能通过去泛素化剪接体蛋白 PRPF3 调节 mRNA 剪接，从而影响 U4/U6.U5 snRNP 的稳定性；此外，还可能参与内质网质量调控。by similar：USP4 的去泛素化活性涉及多种底物，包括信号通路蛋白、受体和剪接体组分，表明其在细胞调控中具有广泛作用。

Active

Human

Sf9 insect cells

His;Flag

Q13107-1 (A2-N963)

7375

Partial

Greater than 80% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 5% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.